CIRCHIPK3 REGULATES CARDIAC FIBROBLAST PROLIFERATION, MIGRATION AND PHENOTYPIC SWITCHING THROUGH THE MIR-152-3P/TGF-β2 AXIS UNDER HYPOXIA

CircHIPK3 regulates cardiac fibroblast proliferation, migration and phenotypic switching through the miR-152-3p/TGF-β2 axis under hypoxia

Background The occurrence of pathological cardiac fibrosis is attributed to tissue hypoxia.Circular RNAs play significant regulatory roles in multiple cardiovascular diseases and are involved in the regulation of physiological and pathophysiological processes.CircHIPK3 has been identified as the one of the most crucial regulators in cardiac fibrosi

read more


COVID-19: epidemiología, virología y transmisibilidad

Hasta diciembre del 2019, seis tipos de coronavirus ya estaban identificados como generadores de enfermedad en humanos, destacándose dos brotes epidemiológicos anteriores: SARS-CoV en 2002 y MERS-CoV en 2012.El nuevo agente infeccioso que causó la pandemia de 2019 se denominó SARS-CoV-2, el que se manifiesta como un ashy bines protein powder sÃ

read more


Extra-Low-Frequency Pulse Stimulated Conformational Change in Blood-Cell Proteins and Consequent Immune Activity Transformation

Objective: investigation of the extra-low-frequency (ELF) stimulation effect on blood-cell proteins, that causes variation in its electrostatic-state.A hypothesis that this results in the conformational change in the blood-cell proteins which could enhance immune activity is explored.Since HIV-1 and host-cell engage through charge-charge interactio

read more